Tree of Life — 30 Oct 2025

Environmental influences on genetics or gene expression

Kazeem – environmental influences on gene expression – e.g. Himalayan rabbits, where coat patterns are determined by temperature https://www.nature.com/scitable/topicpage/environmental-influences-on-gene-expression-536/

Also Siamese cats, and numerous influences of temperature on developmental form and process

GC content and free energy — https://www.sciencedirect.com/science/article/pii/S004763740500120X

Bubble formation with temperature less likely with AT-rich sequences

Leila – DNA methylation influenced by environment? https://elifesciences.org/articles/5255

Environmental effects were limited to transposons, where CHH methylation was found to increase with temperature

Unlike CHH methylation, CpG gene body methylation (GBM) was not affected by growth temperature, but was instead correlated with the latitude of origin.

Transposable elements – mariner, line 1 elements, etc https://en.wikipedia.org/wiki/Tc1/mariner

Placenta has viral origins https://www.polytechnique-insights.com/en/columns/health-and-biotech/the-placenta-a-legacy-inherited-from-ancient-viruses/

Robert https://www.annualreviews.org/content/journals/10.1146/annurev-ecolsys-110512-135907 How complexity evolves, eye case study

Peppered moth and industrial melanism

Evo-devo

Immune system and genetic variation within it; temperature and other covariates

Bat immune systems are flexible; associated with transition to flying life mode

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