Placenta properties and development (and mitochondria?)
Kazeem — https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.13172
Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy
Two distinct cell layers with different mitochondrial properties
Cytotrophoblast differentiation into the syncytiotrophoblast leads to decreased mitochondrial respiration and altered metabolism, including an increase in lactate production.19 The syncytiotrophoblast forms the outer layer of the placenta in direct contact with maternal systems, and appears to be the placental region most responsive to changes in oxygen levels; this responsiveness is likely partly due to the unique mitochondria of the syncytiotrophoblast, and may help the placental/fetal unit adapt to maternal conditions.20
Robert — https://www.sciencedirect.com/science/article/pii/S0143400406002724?via%3Dihub
Comparison of animal and human placenta formation
Mitochondrial function and structure in placental disorders
https://www.sciencedirect.com/science/article/pii/S0143400416306592?via%3Dihub
STB mitochondria specialised for steroid biogenesis
- Signalling to mother’s tissues? Suppress immune system?
- Perhaps explains smaller mitos with less cristae (ATP synthase dimers) t has been suggested that these morphological changes are related to steroidogenesis, as cholesterol could be more efficiently transported to P450scc in the inner mitochondrial membrane in smaller mitochondria. Lower cardiolipin too, reduced membrane potential, higher ROS
Preeclampsia linked to mito dysfunction, lower CIII e- flow, etc
Iain – phylogenomics of placenta – mutational profiles akin to cancer
https://www.nature.com/articles/s41586-021-03345-1
also segregation of mtDNA in placental development. Looks compatible with Kimura distribution but could be interesting
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